My 11yo Lab/Redbone Hound, Mack, was diagnosed with Granulamatosis Menengial Encephilatous (sp?) aka: GME in mid-May. I VERY seriously doubt he would've survived that night, for us to get him to the vet in the morning, were it not for my squirting diluted MMS1 into his mouth several times over the course of the night. (He was in too bad of shape to even raise his head to drink.) My vet's a good guy; and, open-minded; but, has only conventional training. His "solution" was antibiotics and prednizone... (With conventional treatment, the average diagnosis to death time is 8 days for focal GME, which is what Mack has/had/???.) He's too large for me to carry; so, I did intersperse his meds with MMS for the first day. His left hind leg was swollen 3 times its normal size; and, his right leg wouldn't hold him up. I was able to get the swelling down by mixing NFZ, MMS1, and DMSO; and, after washing the leg really well with MMS2 spray, slathering his leg from toes to hip with this mixture, and wrapping it with saranwrap for 12 hours. Once the swelling was gone and he could help me move him, I tossed the pills and started dosing him every hour with MMS1. Progress was slow that 1st day; but, rapid after that. Within about 3 days, Mack was doing better than he had in months. I started scaling back to a maintainance dose of 2 drops twice a day. He was on that until about 4 days ago. I needed to worm him and do heartworm preventative; and, I didn't want to risk Herx'ing him. Also, I had started questioning whether or not he still needed to be on a maintainance dose; and, even if the diagnosis had been correct. I took him off for about 2 days.... BIG MISTAKE; and, one that came all too close to being fatal for him...  By Wed. night, he was pretty well comatose. I was having to drizzle diluted MMS1, mixed with a drop of DMSO, across his tongue and gums. He was unconscious and I wasn't even getting reflexive swallowing (I was being careful not to aspirate him.) The only way I even knew that he was still alive was that I could see shallow breathing, by watching his side. I continued doing this for about an hour and a half before he finally opened his eyes and raised his head. Shortly after that, he got up on his own and went outside. He wasn't too steady on his feet; but, he was able to go out and pee with my just "spotting him." We got back inside and I mixed him a dose in broth, which he lapped up. An hour later, I went to get a can of dog food, to mix it into, to see if he'd eat. I turned around and discovered that he'd followed me the 50 yards or so I'd had to go to get the can. (I have a really weird living arrangement out here, due to my home burning to the ground back in Jan.) It's now Fri. night/Sat. morning; and, he's back to moving around normally. I've backed off to dosing him at about 4 hour intervals, with about a 6 hour gap for me to get some sleep; and, I'll be working towards getting him back to 2 drops twice a day; but, barring my finding a way to safely get to the root cause (which is microsporidia in the spinal fluid), he's going to be kept on a maintainance dose the rest of his life. Also, I'm not going to be getting complacent again. This last time, there wasn't any focal swelling that I could see; but,  if I'd been asleep (etc.), I'd have been burying Mack on Thurs........ (And, "kicking myself in the butt" even worse than I am now.) Instead, he's laying right outside (where it's cool) and waiting to follow me back to "the micro" (I'm still trying to finish; but, has air conditioning.)